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Nature 375 (6526):813 Ma M, Jiang W, Zhou R (2024) DAMPs and DAMP-sensing receptors in inflammation and diseases
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In acute gout, MSU crystals, liberated from tissue deposits by remodeling effects or microtrauma, stimulate inflammatory cascades that involve complement activation and assembly of the C5b-9 membrane attack complex, and release of multiple inflammatory cytokines, including IL-1 and the chemokines IL-8 (CXCL8) and GRO- (CXCL1)
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